A potential rabies outbreak causes panic among the residents of Poplar. Trixie cares for a patient experiencing difficult labor. Cyril meets Rosalind’s parents, but as the day progresses, the atmosphere becomes brittle and strained.

Trixie cares for a single mother recently discharged from a psychiatric hospital. An outbreak of gonorrhea sees Shelagh and Miss Higgins using the Council’s new tracing system to identify contacts for testing and treatment.

Sister Frances finds herself in a tricky situation when a pregnant woman confides in her. Trixie is troubled by her sudden admittance to the Lady Emily. Cyril helps an evicted family find shelter. Sister Julienne’s new venture hits a stumbling block.

While Trixie tries to calm an anxious patient, Sister Frances examines a young woman with some troubling symptoms. Lucille helps support a single mother through her fourth pregnancy and intervenes when authorities question her capabilities as a mother.

Join the home cooks as the competition heats up with challenges for their best in-a-pinch recipe and a noodle dish representing their heritage. All kinds of dishes show up on the plate, but one cook is ready to impress by making their own pasta.

Shelagh and Joyce assist a heavily pregnant woman dealing with a severe mold infestation in her new flat. Nancy attends a “Raise the Roof Campaign” meeting against some of her peers’ wishes. Trixie takes secret driving lessons from Fred.

Siegfried has the bright idea of bringing in an experienced bookkeeper, Miss Harbottle, to bring method to their madness. James and Helen take inspiration from Siegfried’s ‘Carpe Diem’ approach and make a long-awaited decision.

Six of the South’s most influential creators take us home to the places that define them: author Angie Thomas to Mississippi; singer/songwriter Jason Isbell to his musical Alabama roots while Amanda Shires takes us to the farm the couple shares; Michael Twitty revisits rural Alabama; Lyle Lovett remembers the Texas of his childhood; and Qui Nguyen returns to his Arkansas small town.

Fresh from veterinary college, Siegfried’s fun-loving brother, Tristan, arrives to help out. Mrs. Pumphrey throws a swanky party.

Hopeful of a closer relationship with Helen, James invites her to the gala spring dance. Siegfried also tries his luck with romance.

James and Helen enter married life, while James settles in uneasily as Siegfried’s partner at the clinic. Tristan too must make new adjustments.

Lucille struggles with her mental and emotional health; Sister Julienne is deeply concerned by an angry red rash on a patient’s breast and a referral is quickly made to St Cuthbert’s.

Lady Denham plans an elaborate luncheon to welcome the wealthy West Indian heiress Miss Lambe to town – and to seal a match for her nephew, Edward. Charlotte and Sidney have an awkward confrontation.

Charlotte starts a new job, Alison longs for her knight in shining armor, and Georgiana receives bad news.

Georgiana faces a nearly impossible task in trying to find a lawyer, but help arrives from a surprising place. Lady Denham accepts a new vision for the town and spars with an old flame. Arthur makes a new friend.